About this srcd poster session

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Panel information
Panel 6. Developmental Psychopathology

Abstract

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Background: Humans are inevitably exposed to multiple physical and social environmental risk factors, however, the combined effects of prenatal air pollution and psychosocial environments on child cognition and mental health remain unclear.
Objective: This study aims to estimate how prenatal PM2.5 exposure interacts with social environments (i.e., neighborhood) to affect cognitive performance and psychotic-like experiences (PLEs) in a large-scale population sample in the United States.
Methods: We analyzed data from 6,092 participants (aged 9-10 years) from the Adolescent Brain Cognitive Development (ABCD) Study®. Daily estimates of prenatal PM2.5 exposure were assigned to the primary residential address during prenatal period using an ensemble-based modeling approach. Caregivers assessed neighborhood safety and crime presence through three items at baseline. Cognitive performance was measured by the NIH Toolbox Cognition Battery (CB) including seven neurocognitive tasks; from the CB we obtained age-corrected total composite scores at baseline and 2-year follow-up. PLEs were estimated using the Prodromal Questionnaire Brief Child Version (PQ-BC) completed by children, a 21-item self-report questionnaire; we used the distress scores at baseline and 2-year follow-up. Moderation models with cluster-robust standard errors were constructed to examine the interaction between prenatal PM2.5 exposure and neighborhood environment on child cognition and PLEs, adjusting for sex, age, race, cognition and PLEs scores at baseline.
Results: Neighborhood environment significantly moderated the association between prenatal PM2.5 exposure and cognition. Greater prenatal PM2.5 predicted poorer cognitive performance only when children were situated in an unsafety neighborhood environment. However, neighborhood environment did not significantly moderate the relationship between PM2.5 and PLEs.
Conclusion: This longitudinal study is the first to demonstrate that combined exposure to prenatal PM2.5 pollutant and adverse neighborhood environment affects child cognitive function, adding to existing evidence that co-exposure to multiple environmental risk factors affects cognition development in children over time.

Author information

Author	Role
Tianjiao Kong, Beijing Normal University	Presenting author
Yumeng Yang, Beijing Normal University	Non-presenting author
Feng Ji, University of Toronto	Non-presenting author
Jia Liu, Beijing Normal University	Non-presenting author
Ran Liu, Beijing Normal University	Non-presenting author
Liang Luo, Beijing Normal University	Non-presenting author

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